New data show that fertility is possible in women who survive childhood cancer. The challenge is to identify which patients will be left infertile by cancer treatment and who might be able to conceive.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Encapsulation of ovarian allograft precludes immune rejection and promotes restoration of endocrine function in immune-competent ovariectomized mice
Scientific Reports Open Access 12 November 2019
-
Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles
Stem Cell Research & Therapy Open Access 21 March 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Barton, S. E. et al. Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort. Lancet Oncol. 14, 873–881 (2013).
Childhood Cancer Survivor Study. [online], (2013).
Jeruss, J. S. & Woodruff, T. K. Preservation of fertility in patients with cancer. N. Engl. J. Med. 360, 902–911 (2009).
Brougham, M. F. et al. Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study. J. Clin. Endocrinol. Metab. 97, 2059–2067 (2012).
Ernst, E., Kjærsgaard, M., Birkebæk, N. H., Clausen, N. & Andersen, C. Y. Case report: stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. Eur. J. Cancer 49, 911–914 (2013).
Donnez, J. et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil. Steril. 99, 1503–1513 (2013).
Ernst, E. H., Offersen, B. V., Andersen, C. Y. & Ernst, E. Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence. J. Assist. Reprod. Genet. 30, 975–978 (2013).
Wang, C., Chen, M., Fu, F. & Huang, M. Gonadotropin-releasing hormone analog cotreatment for the preservation of ovarian function during gonadotoxic chemotherapy for breast cancer: a meta-analysis. PLoS ONE 8, e66360 (2013).
Kim, S. Y. et al. Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell Death Differ. 20, 987–997 (2013).
Chemaitilly, W. & Sklar, C. A. Endocrine complications in long-term survivors of childhood cancers. Endocr. Relat. Cancer 17, R141–R159 (2010).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Woodruff, T. Fertility in female survivors of childhood cancer. Nat Rev Endocrinol 9, 571–572 (2013). https://doi.org/10.1038/nrendo.2013.170
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2013.170
This article is cited by
-
A synopsis of global frontiers in fertility preservation
Journal of Assisted Reproduction and Genetics (2022)
-
Enhanced method to select human oogonial stem cells for fertility research
Cell and Tissue Research (2021)
-
Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles
Stem Cell Research & Therapy (2019)
-
Encapsulation of ovarian allograft precludes immune rejection and promotes restoration of endocrine function in immune-competent ovariectomized mice
Scientific Reports (2019)