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Metabolism

Adiponectin—a mediator of specific metabolic actions of FGF21

Adiponectin and fibroblast growth factor 21 (FGF21) regulate glucose and lipid metabolism in similar ways and are both critically involved in the antidiabetic effects of thiazolidinedione drugs. Studies in mice now shed light on how adiponectin and FGF21 are functionally linked, which has intriguing implications for the therapeutic potential of these hormones.

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Figure 1: Model of the regulatory connections between PPARγ, FGF21 and adiponectin in adipose tissue.

References

  1. Lin, Z. et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17, 779–789 (2013).

    Article  CAS  PubMed  Google Scholar 

  2. Holland, W. L. et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab. 17, 790–797 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kliewer, S. A. & Mangelsdorf, D. J. Fibroblast growth factor 21: from pharmacology to physiology. Am. J. Clin. Nutr. 91, 254S–257S (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Dutchak, P. A. et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148, 556–567 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Fisher, F. M. et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271–281 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Shklyaev, S. et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc. Natl Acad. Sci. USA 100, 14217–14222 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Berg, A. H., Combs, T. P., Du, X., Brownlee, M. & Scherer, P. E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947–953 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Yamauchi, T. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941–946 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Turer, A. T. & Scherer, P. E. Adiponectin: mechanistic insights and clinical implications. Diabetologia 55, 2319–2326 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Kharitonenkov, A. et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148, 774–781 (2007).

    Article  CAS  PubMed  Google Scholar 

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Goetz, R. Adiponectin—a mediator of specific metabolic actions of FGF21. Nat Rev Endocrinol 9, 506–508 (2013). https://doi.org/10.1038/nrendo.2013.146

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