Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Novel target to enhance radioiodine uptake in thyroid cancer

Nature Reviews Endocrinology volume 9, pages 508–509 (2013)Cite this article

Subjects

The sodium–iodide symporter mediates iodide uptake, but its activity is reduced by the overexpression of pituitary tumour-transforming gene 1 protein-binding factor (PBF) in thyroid tumours. A recent study shows that inhibiting PBF phosphorylation enhances radioiodine uptake in thyroid cancer models.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kogai, T., Taki, K. & Brent, G. A. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr. Relat. Cancer 13, 797–826 (2006).

    Article  CAS  Google Scholar 

  2. Smith, V. E. et al. Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2012–3640.

  3. Smith, V. E. et al. A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer. J. Cell Sci. 122, 3393–3402 (2009).

    Article  CAS  Google Scholar 

  4. Watkins, R. J. et al. Pituitary tumor transforming gene binding factor: a new gene in breast cancer. Cancer Res. 70, 3739–3749 (2010).

    Article  CAS  Google Scholar 

  5. Read, M. L. et al. Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment. Cancer Res. 71, 6153–6164 (2011).

    Article  CAS  Google Scholar 

  6. Kogai, T. & Brent, G. A. The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics. Pharmacol. Ther. 135, 355–370 (2012).

    Article  CAS  Google Scholar 

  7. Kogai, T., Sajid-Crockett, S., Newmarch, L. S., Liu, Y. Y. & Brent, G. A. Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J. Endocrinol. 199, 243–252 (2008).

    Article  CAS  Google Scholar 

  8. Chakravarty, D. et al. Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J. Clin. Invest. 121, 4700–4711 (2011).

    Article  CAS  Google Scholar 

  9. Ho, A. L. et al. Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N. Engl. J. Med. 368, 623–632 (2013).

    Article  CAS  Google Scholar 

  10. Lewy, G. D. et al. The pituitary tumor transforming gene in thyroid cancer. J. Endocrinol. Invest. 35, 425–433 (2012).

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors' research is supported by the Department of Veterans Affairs Research Funds and an NIH grant (RO1 CA89364).

Author information

Authors and Affiliations

  1. Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, 90073, CA, USA

    Gregory A. Brent

  2. Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, 321-0293, Tochigi Prefecture, Japan

    Takahiko Kogai

Authors
  1. Gregory A. Brent
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takahiko Kogai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gregory A. Brent.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brent, G., Kogai, T. Novel target to enhance radioiodine uptake in thyroid cancer. Nat Rev Endocrinol 9, 508–509 (2013). https://doi.org/10.1038/nrendo.2013.132

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2013.132

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing