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Pituitary gland

New pathways in the pathogenesis of pituitary adenomas

Acromegaly is caused by a growth-hormone-secreting pituitary adenoma. Mutations in the AIP gene predispose patients to young-onset pituitary adenomas that are resistant to somatostatin analogue therapy. Chalal et al. describe a potential mechanism by which AIP modulates responsiveness to somatostatin analogues and identify PLAGL1 as a potential modulator of therapeutic activity.

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Acknowledgements

The authors wish to thank the Melvin Burkhardt Chair in Neurosurgical Oncology and the Karen Colina Wilson Research endowment in the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center at the Cleveland Clinic.

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Correspondence to Robert J. Weil.

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The authors declare no competing financial interests.

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Marko, N., Weil, R. New pathways in the pathogenesis of pituitary adenomas. Nat Rev Endocrinol 8, 572–573 (2012). https://doi.org/10.1038/nrendo.2012.143

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