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Cancer

Thyroid cancer bone metastases and high morbidity rates

Skeletal-related events (SREs) are important measures of morbidity and mortality in patients with solid tumour bone metastases. The high rate of SREs in patients with differentiated thyroid cancer bone metastases reported by Farooki et al. indicates that routine use of antiresorptive therapy in these patients could result in reduced SREs.

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References

  1. Rosen, L. S. et al. Zoledronic acid versus placebo in the treatment of skeletal metastases in patients with lung cancer and other solid tumors: a phase III, double-blind, randomized trial—the Zoledronic Acid Lung Cancer and Other Solid Tumors Study Group. J. Clin. Oncol. 21, 3150–3157 (2003).

    Article  CAS  Google Scholar 

  2. Henry, D. H. et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J. Clin. Oncol. 29, 1125–1132 (2011).

    Article  CAS  Google Scholar 

  3. Durante, C. et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J. Clin. Endocrinol. Metab. 91, 2892–2899 (2006).

    Article  CAS  Google Scholar 

  4. Farooki, A., Leung, V., Tala, H. & Tuttle, R. M. Skeletal-related events due to bone metastases from differentiated thyroid cancer. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2012-1169.

  5. Orita, Y., Sugitani, I., Toda, K., Manabe, J. & Fujimoto, Y. Zoledronic acid in the treatment of bone metastases from differentiated thyroid carcinoma. Thyroid 21, 31–35 (2011).

    Article  CAS  Google Scholar 

  6. Domchek, S. M., Younger, J., Finkelstein, D. M. & Seiden, M. V. Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89, 363–368 (2000).

    Article  CAS  Google Scholar 

  7. Coleman, R. E. Bisphosphonates: clinical experience. Oncologist 9 (Suppl. 4), 14–27 (2004).

    Article  CAS  Google Scholar 

  8. Kazaure, H. S., Roman, S. A. & Sosa, J. A. Insular thyroid cancer: a population-level analysis of patient characteristics and predictors of survival. Cancer 118, 3260–3267 (2012).

    Article  Google Scholar 

  9. Muresan, M. M. et al. Bone metastases from differentiated thyroid carcinoma. Endocr. Relat Cancer 15, 37–49 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Electron Kebebew.

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Gramza, A., Kebebew, E. Thyroid cancer bone metastases and high morbidity rates. Nat Rev Endocrinol 8, 454–455 (2012). https://doi.org/10.1038/nrendo.2012.112

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