Prevailing guidelines advocate a low-salt diet to mitigate progression of renal and cardiovascular disease in patients with diabetes mellitus. However, two recent cohort studies in patients with type 1 and type 2 diabetes mellitus associate lower salt intake with increased rates of end-stage renal disease, cardiovascular death and all-cause mortality.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tierney, J. Salt wars. The New York Times TierneyLab Blog [online], (2010).
Bantle, J. P. et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 31 (Suppl. 1), S61–S78 (2008).
Taubes, G. The (political) science of salt. Science 281, 898–901, 903–907 (1998).
Ekinci, E. I. et al. Dietary salt intake and mortality in patients with type 2 diabetes. Diabetes Care 34, 703–709 (2011).
Thomas, M. C. et al. The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes. Diabetes Care 34, 861–866 (2011).
Thomson, S. C., Vallon, V. & Blantz, R. C. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am. J. Physiol. Renal. Physiol. 286, F8–F15 (2004).
Vallon, V. The proximal tubule in the pathophysiology of the diabetic kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R1009–R1022 (2011).
Pruijm, M. et al. Glomerular hyperfiltration and increased proximal sodium reabsorption in subjects with type 2 diabetes or impaired fasting glucose in a population of the African region. Nephrol. Dial. Transplant. 25, 2225–2231 (2010).
Mogensen, C.E. Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathy. Scand. J. Clin. Lab. Invest. 46, 201–206 (1986).
Rigalleau, V. et al. Large kidneys predict poor renal outcome in subjects with diabetes and chronic kidney disease. BMC Nephrol. 11, 3 (2010).
Acknowledgements
Work by the authors was supported by the NIH (R01DK56248, R01HL094728, P30DK079337), the American Heart Association (GRNT3440038) and the Department of Veterans Affairs.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Vallon, V., Thomson, S. Anomalous role for dietary salt in diabetes mellitus?. Nat Rev Endocrinol 7, 377–378 (2011). https://doi.org/10.1038/nrendo.2011.90
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2011.90
This article is cited by
-
Urinary sodium excretion and kidney failure in nondiabetic chronic kidney disease
Kidney International (2014)