Mutations in genes encoding transcription factors that control pituitary development cause early-onset pituitary hormone deficiencies. Now, circulating antibodies against one such factor, PIT1, have been identified as being responsible for hormone deficits and pituitary cell loss similar to those caused by mutations of its gene POU1F1 but with a late onset.
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A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome
Scientific Reports Open Access 20 February 2017
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Drouin, J., Takayasu, S. Acquired versus inherited pituitary deficiency—same difference?. Nat Rev Endocrinol 7, 255–256 (2011). https://doi.org/10.1038/nrendo.2011.53
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DOI: https://doi.org/10.1038/nrendo.2011.53
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A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome
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