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Epigenetics and metabolism in 2011

Epigenetics, the life-course and metabolic disease

Nature Reviews Endocrinology volume 8, pages 74–76 (2012)Cite this article

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Clinical and experimental studies suggest that early life experiences, perhaps spanning multiple generations, affect lifelong risk of metabolic dysfunction through epigenetic mechanisms. Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis.

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References

  1. Fernandez-Twinn, D. S. & Ozanne, S. E. Early life nutrition and metabolic programming. Ann. NY Acad. Sci. 1212, 78–96 (2010).

    Article  CAS  Google Scholar 

  2. Sandovici, I. et al. Maternal diet and aging alter the epigenetic control of a promoter–enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc. Natl Acad. Sci. USA 108, 5449–5454 (2011).

    Article  CAS  Google Scholar 

  3. Gluckman, P. D. et al. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc. Natl Acad. Sci. USA 104, 12796–12800 (2007).

    Article  CAS  Google Scholar 

  4. Pinney, S., Jaeckle Santos, L., Han, Y., Stoffers, D. & Simmons, R. Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat. Diabetologia 54, 2606–2614 (2011).

    Article  CAS  Google Scholar 

  5. Gale, C. R. et al. Maternal diet during pregnancy and carotid intima-media thickness in children. Arterioscler. Thromb. Vasc. Biol. 26, 1877–1882 (2006).

    Article  CAS  Google Scholar 

  6. Godfrey, K. M. et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 60, 1528–1534 (2011).

    Article  CAS  Google Scholar 

  7. Toperoff, G. et al. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum. Mol. Genet. http://dx.doi.org/10.1093/hmg/ddr472.

  8. Poston, L., Harthoorn, L. F. & Van Der Beek, E. M. on behalf of contributors to the ILSI Europe workshop. Obesity in pregnancy: implications for the mother and lifelong health of the child. a consensus statement. Pediatr. Res. 69, 175–180 (2011).

    Article  Google Scholar 

  9. Dunn, G. A. & Bale, T. L. Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology 152, 2228–2236 (2011).

    Article  CAS  Google Scholar 

  10. Hammoud, S. S. et al. Distinctive chromatin in human sperm packages genes for embryo development. Nature 460, 473–478 (2009).

    Article  CAS  Google Scholar 

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Acknowledgements

F. Low provided assistance with reviewing the literature.

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  1. Liggins Institute, The University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand

    Peter D. Gluckman

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  1. Peter D. Gluckman
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Gluckman, P. Epigenetics, the life-course and metabolic disease. Nat Rev Endocrinol 8, 74–76 (2012). https://doi.org/10.1038/nrendo.2011.226

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