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Treatment of type 2 diabetes mellitus with bariatric surgery

Gastrointestinal surgery may ameliorate glycemic control in type 2 diabetes mellitus within days to weeks—an effect that cannot be explained solely by the changes in food intake and body weight following gastric bypass. Should clinicians, therefore, implement bariatric procedures to treat type 2 diabetes mellitus in patients who do not meet current obesity-based criteria for surgery?

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  1. Rubino, F., Kaplan, L. M., Schauer, P. R. & Cummings, D. E. The Diabetes Surgery Summit Consensus Conference: Recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus. Ann. Surg. doi:10.1097/sla.0b013e3181be34e7.

    Article  PubMed  Google Scholar 

  2. Buchwald H. et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 292, 1724–1737 (2004).

    CAS  Article  Google Scholar 

  3. Sjöström, L. et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N. Engl. J. Med. 351, 2683–2693 (2004).

    Article  PubMed  Google Scholar 

  4. Dixon, J. B. et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299, 316–323 (2008).

    CAS  Google Scholar 

  5. Segato, G. et al. Weight loss and changes in use of antidiabetic medication in obese type 2 diabetics after laparoscopic gastric banding. Surg. Obes. Relat. Dis. doi:10.1016/j.soard.2009.09.014.

    Article  PubMed  Google Scholar 

  6. Tice, J. A., Karliner, L., Walsh, J., Petersen, A. J. & Feldman, M. D. Gastric banding or bypass? A systematic review comparing the two most popular bariatric procedures. Am. J. Med. 121, 885–893 (2008).

    Article  Google Scholar 

  7. Chapman, A. E. et al. Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery 135, 326–351 (2004).

    Article  PubMed  Google Scholar 

  8. Angrisani, L., Lorenzo, M. & Borrelli, V. Laparoscopic adjustable gastric banding versus Roux-en-Y gastric bypass: 5-year results of a prospective randomized trial. Surg. Obes. Relat. Dis. 3, 127–132 (2007).

    Article  PubMed  Google Scholar 

  9. Saliba, J., Wattacheril, J. & Abumrad, N. N. Endocrine and metabolic response to gastric bypass. Curr. Opin. Clin. Nutr. Metab. Care 12, 515–521 (2009).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. Gumbs, A. A., Modlin, I. M. & Ballantyne, G. H. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes. Surg. 15, 462–473 (2005).

    Article  Google Scholar 

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Clifton, P. Treatment of type 2 diabetes mellitus with bariatric surgery. Nat Rev Endocrinol 6, 191–193 (2010).

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