Vitamin D deficiency increases the risk of autoimmune, cardiovascular and infectious diseases, type 2 diabetes mellitus, as well as the risk of falls and fractures. Several prospective, randomized, controlled trials published in 2010 highlight the importance of improving vitamin D status in children and adults to reduce the risk of upper respiratory tract infections and cardiovascular disease, amongst other disorders.
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Holick, M. F. Vitamin D deficiency. N. Eng. J. Med. 357, 266–281 (2007).
Urashima, M. et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am. J. Clin. Nutr. 91, 1255–1260 (2010).
Brehm, J. M. et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J. Allergy Clin. Immunol. 126, 52.E5–58.E5 (2010).
Sabetta, J. R. et al. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS ONE 14, E11088 (2010).
Reis, J. P., von Mühlen, D., Miller, E. R. 3rd, Michos, E. D. & Appel, L. J. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 124, E371–E379 (2009).
Dong, Y. et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J. Clin. Endocrinol. Metab. 95, 4584–4591 (2010).
Oh, J. et al. 1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation 120, 687–698 (2009).
Lindqvist, P. G., Olsson, H. & Landin-Olsson, M. Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? Diabetes Res. Clin. Pract. 90, 109–114 (2010).
Pittas, A. G., Lau, J., Hu, F. B. & Dawson-Hughes, B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 92, 2017–2029 (2007).
Ross, A. C., Taylor, C. L., Yaktine, A. L. & Del Valle, H. B. (Eds) Dietary Reference Intakes for Calcium and Vitamin D. (The National Academies Press, Washington DC, 2011).
The author declares no competing financial interests.
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Holick, M. Health benefits of vitamin D and sunlight: a D-bate. Nat Rev Endocrinol 7, 73–75 (2011). https://doi.org/10.1038/nrendo.2010.234
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