Vitamin D deficiency increases the risk of autoimmune, cardiovascular and infectious diseases, type 2 diabetes mellitus, as well as the risk of falls and fractures. Several prospective, randomized, controlled trials published in 2010 highlight the importance of improving vitamin D status in children and adults to reduce the risk of upper respiratory tract infections and cardiovascular disease, amongst other disorders.
This is a preview of subscription content, access via your institution
Open Access articles citing this article.
Scientific Reports Open Access 28 June 2017
Vitamin D supplementation for the prevention of type 2 diabetes in overweight adults: study protocol for a randomized controlled trial
Trials Open Access 07 August 2015
Subscribe to Journal
Get full journal access for 1 year
only $8.25 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Holick, M. F. Vitamin D deficiency. N. Eng. J. Med. 357, 266–281 (2007).
Urashima, M. et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am. J. Clin. Nutr. 91, 1255–1260 (2010).
Brehm, J. M. et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J. Allergy Clin. Immunol. 126, 52.E5–58.E5 (2010).
Sabetta, J. R. et al. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS ONE 14, E11088 (2010).
Reis, J. P., von Mühlen, D., Miller, E. R. 3rd, Michos, E. D. & Appel, L. J. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 124, E371–E379 (2009).
Dong, Y. et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J. Clin. Endocrinol. Metab. 95, 4584–4591 (2010).
Oh, J. et al. 1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation 120, 687–698 (2009).
Lindqvist, P. G., Olsson, H. & Landin-Olsson, M. Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? Diabetes Res. Clin. Pract. 90, 109–114 (2010).
Pittas, A. G., Lau, J., Hu, F. B. & Dawson-Hughes, B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 92, 2017–2029 (2007).
Ross, A. C., Taylor, C. L., Yaktine, A. L. & Del Valle, H. B. (Eds) Dietary Reference Intakes for Calcium and Vitamin D. (The National Academies Press, Washington DC, 2011).
The author declares no competing financial interests.
About this article
Cite this article
Holick, M. Health benefits of vitamin D and sunlight: a D-bate. Nat Rev Endocrinol 7, 73–75 (2011). https://doi.org/10.1038/nrendo.2010.234
Indian Academy of Pediatrics Revised (2021) Guidelines on Prevention and Treatment of Vitamin D Deficiency and Rickets
Indian Pediatrics (2022)
Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor–binding protein-1 (HBp17/FGFBP-1)
In Vitro Cellular & Developmental Biology - Animal (2020)
The journal of nutrition, health & aging (2019)
Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study
European Journal of Nutrition (2018)
Scientific Reports (2017)