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Does celiac disease trigger autoimmune thyroiditis?

Nature Reviews Endocrinology volume 5, pages 190191 (2009) | Download Citation


Autoimmune thyroiditis has increased prevalence in patients with celiac disease and vice versa. New research suggests that serum transglutaminase 2 autoantibodies, which are present in patients with celiac disease, might have a role in the development of thyroid dysfunction.

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  1. 1.

    , , & . Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis. Mucosal Immunol. 2, 8–23 (2009).

  2. 2.

    . et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N. Engl. J. Med. 359, 2767–2777 (2008).

  3. 3.

    , & . Celiac disease and autoimmune thyroid disease. Clin. Med. Res. 5, 184–192 (2007).

  4. 4.

    et al. A common CTLA4 polymorphism confers susceptibility to autoimmune thyroid disease in celiac children. Dig. Liver Dis. [doi:10.1016/j.dld.2008.09.001] (2008).

  5. 5.

    , , & Endocrinological disorders and celiac disease. Endocr. Rev. 23, 464–483 (2002).

  6. 6.

    et al. Tissue transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid dysfunction. Thyroid 18, 1171–1178 (2008).

  7. 7.

    , & Clinical inquiries: what blood tests help diagnose celiac disease? J. Fam. Pract. 55, 1088–1093 (2006).

  8. 8.

    et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355, 1518–1519 (2000).

  9. 9.

    et al. Lower economic status and inferior hygienic environment may protect against celiac disease. Ann. Med. 40, 223–231 (2008).

  10. 10.

    et al. Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments. J. Clin. Endocrinol. Metab. 93, 729–734 (2008).

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I would like to thank Ms Maria Panoutsopoulou for her valuable assistance in the preparation of this manuscript.

Author information


  1. Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, Athens, Greece.

    • Leonidas H. Duntas


  1. Search for Leonidas H. Duntas in:

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The author declares no competing financial interests.

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