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US recommendations fail to correct vitamin D deficiency

Vitamin D deficiency is widespread among women with breast cancer. Guidelines currently recommend daily supplementation with 400 IU vitamin D3; however, attainment of a circulating level of 25-hydroxyvitamin D defined as sufficient (that is, ≥75 nmol/l) might not be possible with this level of supplementation, according to data published in the Journal of Clinical Oncology.

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Figure 1: Dose–response analysis of serum 25-hydroxyvitamin D levels after vitamin D3 supplementation.


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Correspondence to Bruce W. Hollis.

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Bruce W. Hollis is a consultant for DiaSorin.

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Hollis, B. US recommendations fail to correct vitamin D deficiency. Nat Rev Endocrinol 5, 534–536 (2009).

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