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Calories or content: what is the best weight-loss diet?

Researchers have randomly assigned 811 overweight adults to low-calorie diets with differing percentages of energy derived from protein, carbohydrate, and fat; participants were followed up for 2 years. All groups experienced modest weight loss and improvements in cardiac and diabetes risk factors. Does this finding mean that clinicians can finally advise their patients on the best way to lose weight?

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Correspondence to Jonathan Q. Purnell.

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Purnell, J. Calories or content: what is the best weight-loss diet?. Nat Rev Endocrinol 5, 419–420 (2009).

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