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Sickle cell disease

Nature Reviews Disease Primers volume 4, Article number: 18011 (2018) | Download Citation

This PrimeView is an illustrated summary of the Primer for sickle cell disease. Download the PDF for an accessible version

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This PrimeView highlights the complex pathophysiological mechanisms of sickle cell disease (SCD), which stem from the polymerization of sickle haemoglobin (HbS), a mutant haemoglobin variant. Erythrocytes containing HbS polymers assume the crescent shape that gives SCD its name.

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DOI

https://doi.org/10.1038/nrdp.2018.11

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