Chronic pancreatitis is attributed to alcohol abuse in the majority of cases. Tobacco smoking is an independent risk factor; other causes include genetic factors, metabolic disorders, chronic obstructive causes (for example, ductal stones), autoimmunity and idiopathic mechanisms.
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Chronic pancreatitis. Nat Rev Dis Primers 3, 17061 (2017). https://doi.org/10.1038/nrdp.2017.61