Tumour-induced osteomalacia (TIO) — caused by tumours that secrete fibroblast growth factor 23 — is characterized by hypophosphataemia and skeletal abnormalities. Tumours causing TIO are difficult to locate, as they are often small and can occur in soft tissue or bone anywhere in the body.
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Tumour-induced osteomalacia. Nat Rev Dis Primers 3, 17045 (2017). https://doi.org/10.1038/nrdp.2017.45