Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • PrimeView
  • Published:

Paroxysmal nocturnal haemoglobinuria

Somatic PIGA mutations in haematopoietic stem cells generate erythrocytes that are deficient in glycosylphosphatidylinositol-anchored proteins. These erythrocytes are susceptible to haemolysis by complement activation, which manifests as paroxysmal nocturnal haemoglobinuria. This PrimeView illustrates the complex pathological mechanisms.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers 3, 17029 (2017). https://doi.org/10.1038/nrdp.2017.29

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/nrdp.2017.29

Search

Quick links