Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell (HSC) disease that presents with haemolytic anaemia, thrombosis and smooth muscle dystonias, as well as bone marrow failure in some cases. PNH is caused by somatic mutations in PIGA (which encodes phosphatidylinositol N-acetylglucosaminyltransferase subunit A) in one or more HSC clones. The gene product of PIGA is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; thus, PIGA mutations lead to a deficiency of GPI-anchored proteins, such as complement decay-accelerating factor (also known as CD55) and CD59 glycoprotein (CD59), which are both complement inhibitors. Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. The loss of CD55 and CD59 renders PNH erythrocytes susceptible to intravascular haemolysis, which can lead to thrombosis and to much of the morbidity and mortality of PNH. The accumulation of anaphylatoxins (such as C5a) from complement activation might also have a role. The natural history of PNH is highly variable, ranging from quiescent to life-threatening. Therapeutic strategies include terminal complement blockade and bone marrow transplantation. Eculizumab, a monoclonal antibody complement inhibitor, is highly effective and the only licensed therapy for PNH.
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Acknowledgements
This work was supported in part by a grant from the Aplastic Anemia and MDS International Foundation and the US NIH R01HL133113 (R.A.B.).
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Introduction (R.A.B.); Epidemiology (A.E.D.); Mechanisms/pathophysiology (T.K.); Diagnosis, screening and prevention (R.A.B.); Management (A.H. and R.A.B.); Quality of life (A.E.D.); Outlook (R.A.B.); Overview of the Primer (R.A.B.).
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A.H. has received honoraria from and consulted for Akari Therapeutics, Alexion Pharmaceuticals, Alnylam Pharmaceuticals, Ra Pharmaceuticals and Roche. T.K. has received honoraria and speakers fees from and consulted for Alexion Pharmaceuticals. R.A.B is on the scientific advisory boards of Alexion Pharmaceuticals, Apellis Pharmaceuticals and Achillion Pharmaceuticals; R.A.B. also receives grant funding from Alexion. A.E.D. declares no competing interests.
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Hill, A., DeZern, A., Kinoshita, T. et al. Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers 3, 17028 (2017). https://doi.org/10.1038/nrdp.2017.28
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DOI: https://doi.org/10.1038/nrdp.2017.28
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