Spina bifida is a congenital disorder characterized by failed closure (primary neurulation) or formation (secondary neurulation) of the neural tube, resulting in abnormalities of the vertebral column and/or spinal cord. This PrimeView discusses the risk factors for spina bifida, including myelomeningocele — the most common and disabling form.
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Spina bifida. Nat Rev Dis Primers 1, 15051 (2015). https://doi.org/10.1038/nrdp.2015.51