HIV infection

Abstract

More than 75 million people worldwide have been infected with human immunodeficiency virus (HIV), and there are now approximately 37 million individuals living with the infection. Untreated HIV replication causes progressive CD4+ T cell loss and a wide range of immunological abnormalities, leading to an increased risk of infectious and oncological complications. HIV infection also contributes to cardiovascular disease, bone disease, renal and hepatic dysfunction and several other common morbidities. Antiretroviral drugs are highly effective at inhibiting HIV replication, and for individuals who can access and adhere to these drugs, combination antiretroviral therapy leads to durable (and probably lifelong) suppression of viral replication. Viral suppression enables immune recovery and the near elimination of the risk for developing acquired immune deficiency syndrome (AIDS). Despite effective treatment, HIV-infected individuals have a higher than expected risk of heart, bone, liver, kidney and neurological disease. When used optimally by an infected (or by an uninfected) person, antiretroviral drugs can virtually eliminate the risk of HIV transmission. Despite major advances in prevention sciences, HIV transmission remains common in many vulnerable populations, including men who have sex with men, injection drug users and sex workers. Owing to a lack of widespread HIV testing and the costs and toxicities associated with antiretroviral drugs, the majority of the infected population is not on effective antiretroviral therapy. To reverse the pandemic, improved prevention, treatment and implementation approaches are necessary.

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Figure 1: HIV infection and AIDS.
Figure 2: HIV care cascade.
Figure 3: Key milestones in history of HIV research and care.
Figure 4: The HIV life cycle.
Figure 5: T cell depletion.
Figure 6: HIV prevention strategies.
Figure 7: Quality of life impairment in individuals with HIV infection.
Figure 8: Shock and kill for the cure.

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Acknowledgements

The authors thank E. Abrams, J. Gallant, M. Gandhi, E. Geng, T. Ruel and S. Pillai for advice.

Author information

Introduction (S.G.D.); Epidemiology (S.G.D., A.P. and S.B.); Mechanisms/pathophysiology (S.G.D., J.O. and S.B.); Diagnosis, screening and prevention (S.G.D., J.O. and S.B.); Management (S.G.D. and A.P.); Quality of life (S.G.D. and A.P.); Outlook (S.G.D., J.O., A.P. and S.B.); overview of the Primer (S.G.D).

Correspondence to Steven G. Deeks.

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Competing interests

S.G.D. has consulted for Bristol-Myers Squibb, GlaxoSmithKline, Novartis and Janssen, and has received research support from Gilead and Merck. A.P. has attended various advisory boards, has received speaker fees for meetings in the past 4 years for Gilead Sciences and has received research support from GlaxoSmithKline. J.O. and S.B. declare no competing interests.

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Deeks, S., Overbaugh, J., Phillips, A. et al. HIV infection. Nat Rev Dis Primers 1, 15035 (2015). https://doi.org/10.1038/nrdp.2015.35

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