Abstract
The history of psychopharmacology is littered with type II errors — the rejection of effective compounds in the specious belief that they were inefficacious because they had failed to beat placebo in a controlled trial. Revisiting some of these drugs to establish their receptor profile, and then determining what patentable compounds now on the shelf match that profile, might represent a possible future pathway to drug discovery. This article looks at the special circumstances in which numerous potentially effective drugs were withdrawn in the United States.
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Shorter, E. Looking backwards: a possible new path for drug discovery in psychopharmacology. Nat Rev Drug Discov 1, 1003–1006 (2002). https://doi.org/10.1038/nrd964
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DOI: https://doi.org/10.1038/nrd964
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