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Two decades of new drug development for central nervous system disorders

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Figure 1: Trends in drugs entering clinical trials for central nervous system disorders compared with other therapeutic areas: 1990–2012.
Figure 2: Drugs in clinical trials for central nervous system disorders: 1990–2012.


The authors would like to thank J. Karlawish, B. Hyman, M. Albers and A. Sarpatwari for their comments on an earlier draft.

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Correspondence to Aaron S. Kesselheim.

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Since submission of this manuscript, T.J.H. has been employed by Bain Capital, which has invested in health care companies but had no involvement in the study. The authors' funders, grantors and employers had no role in the design and conduct of the study; collection, management, analysis and intepretation of the data; preparation, review and approval of the manuscript; and decision to submit the manuscript for publication.

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Kesselheim, A., Hwang, T. & Franklin, J. Two decades of new drug development for central nervous system disorders. Nat Rev Drug Discov 14, 815–816 (2015).

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