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Obesity

Reversing resistance to leptin in obesity

Nature Reviews Drug Discovery volume 14, pages 458–459 (2015)Cite this article

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Endoplasmic reticulum (ER) stress in the brain can lead to leptin resistance and thus obesity, so the authors sought to identify compounds that could reinstate ER homeostasis. They analysed the changes in gene expression that were induced in six models of reversal of ER stress in mouse liver and hypothalamus, and used the Connectivity Map (CMAP) database to identify compounds that induced similar changes in the expression of analogous human genes. Of these compounds, celastrol, which is extracted from the 'thunder god vine' Triptergium wilfordii, most strongly effected gene expression changes associated with return to ER homeostasis.

celastrol enhanced the effects of leptin injection on reducing food intake in ob/ob mice

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References

  1. Liu, J. L. et al. Treatment of obesity with celastrol. Cell 161, 999–1011 (2015)

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  1. Natasha Bray
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Bray, N. Reversing resistance to leptin in obesity. Nat Rev Drug Discov 14, 458–459 (2015). https://doi.org/10.1038/nrd4671

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