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What does it take to produce a breakthrough drug?

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Figure 1: Overview of drug development pipeline for hepatitis C virus from 1995–2014.
Figure 2: Attrition profiles across therapeutic areas.

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  • 20 March 2015

    The competing interests statement has been expanded to specify the origins of the funding of BCG's health care practice in more detail.

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The authors gratefully acknowledge the contribution of M. Denslow to this work.

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Correspondence to Dirk Calcoen.

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The authors of this article are employees of The Boston Consulting Group (BCG), a management consultancy that works with the world's leading biopharmaceutical companies on R&D productivity issues across therapeutic areas. The research for this specific article was funded through work performed by BCG's health care practice, including partial funding from Gilead Sciences.

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Calcoen, D., Elias, L. & Yu, X. What does it take to produce a breakthrough drug?. Nat Rev Drug Discov 14, 161–162 (2015). https://doi.org/10.1038/nrd4570

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