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Securing the future of drug discovery for central nervous system disorders

Nature Reviews Drug Discovery volume 13, pages 871–872 (2014)Cite this article

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Innovative partnerships among researchers, patients, regulators, payors and industry are needed to reinvigorate drug discovery for central nervous system disorders. Here, we summarize plans of the Collegium Internationale Neuro-Psychopharmacologicum (CINP) to achieve this goal.

Despite substantial advances in the understanding of central nervous system (CNS) disorders, healthcare systems worldwide face an unprecedented challenge in dealing with the unmet needs in this area (see Further information). Meanwhile, the CNS drug pipeline is failing, for reasons including the unparalleled complexity of the CNS, a lack of interdisciplinary collaborations, increased drug development costs and the higher risk of clinical failure of CNS drugs compared with those in other areas of drug development1.

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References

  1. Riordan, H. & Cutler, N. The death of CNS drug development: overstatement or omen? J. Clin. Stud. 3, 12–15 (2011).

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  2. Zohar, J. et al. A proposal for an updated neuropsychopharmacological nomenclature. Eur. Neuropsychopharmacol. 24, 1005–1014 (2014).

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Acknowledgements

The authors would like to acknowledge M. Loughlin, Z. Baxter and A. Grigg of Inspired Science who provided medical writing and editorial support.

Author information

Authors and Affiliations

  1. Innovation Fund Denmark, Østergade 26a, København K, Copenhagen, DK–1100, Denmark

    Peter Høngaard Andersen

  2. US Food and Drug Administration, Silver Spring, 20993, Maryland, USA

    Richard Moscicki

  3. Department of Psychiatry and Medical Research Council and the Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 2QQ, UK

    Barbara Sahakian

  4. McGill University, 3605 Mountain Street, Montreal, H3G 2M1, Quebec, Canada

    Rémi Quirion

  5. Duke University, and Dean of Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857.,

    Ranga Krishnan

  6. Deutsche Bank, 1 Great Winchester Street, London, EC2N 2EQ, UK

    Tim Race

  7. University of British Columbia, 430–5950 University Boulevard, Vancouver, V6T1Z3, Canada

    Anthony Phillips

Consortia

on behalf of the 2013 CINP Summit Group

  • Peter Høngaard Andersen
  • , Richard Moscicki
  • , Barbara Sahakian
  • , Rémi Quirion
  • , Ranga Krishnan
  • , Tim Race
  •  & Anthony Phillips

Corresponding author

Correspondence to Peter Høngaard Andersen.

Ethics declarations

Competing interests

The author declare no competing financial interests.

Supplementary information

Supplementary information S1 (box)

Attendees at 2013 CINP Summit (PDF 200 kb)

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FURTHER INFORMATION

Report to the US President on propelling innovation in drug discovery, development and evaluation

Best Practice guidance for Pilot EMA HTA Parallel Scientific Advice procedures

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on behalf of the 2013 CINP Summit Group. Securing the future of drug discovery for central nervous system disorders. Nat Rev Drug Discov 13, 871–872 (2014). https://doi.org/10.1038/nrd4489

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  • DOI: https://doi.org/10.1038/nrd4489

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