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Nature Reviews Drug Discovery volume 9, pages 513514 (2010) | Download Citation


In April 2010, sipuleucel-T (Provenge; Dendreon), an autologous cellular immunotherapy, was approved by the US FDA for the treatment of asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer. It is the first therapeutic cancer vaccine to receive FDA approval.

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Author information


  1. Celestia S. Higano is at the Department of Medicine, University of Washington and Fred Hutchinson Cancer Research Center, USA.

    • Celestia S. Higano
  2. Eric J. Small is at the Department of Medicine and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.

    • Eric J. Small
  3. Paul Schellhammer is at the Department of Urology, Eastern Virginia Medical School, USA.

    • Paul Schellhammer
  4. Uma Yasothan and Steven Gubernick are at IMS Health, 7 Harewood Avenue, London NW1 6JB, UK.

    • Uma Yasothan
    •  & Steven Gubernick
  5. Peter Kirkpatrick is at Nature Reviews Drug Discovery.

    • Peter Kirkpatrick
  6. Philip W. Kantoff is at the Department of Medicine, Dana–Farber Cancer Institute, Harvard Medical School, USA.

    • Philip W. Kantoff


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Competing interests

The authors declare no competing financial interests.

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