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Targeting tumour metabolism

    Nature Reviews Drug Discovery volume 9, pages 503–504 (2010)Cite this article

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    Metabolism in cancer cells differs from that in normal cells, but it is only recently that opportunities to specifically target these differences to develop novel anticancer drugs are being revealed. Jim Schnabel investigates new collaborations to harness this potential.

    Investigating the metabolic changes in cancers cells, such as their higher rates of glycolysis (the generation of energy through the metabolism of glucose to pyruvate), has been a basic research focus for decades. But efforts to translate this knowledge into therapies have been held back by the uncertainty of what is driving what, says Eyal Gottlieb, Head of the Apoptosis and Tumour Metabolism Group at the CR-UK-funded Beatson Institute for Cancer Research in Glasgow, UK. “Is the changing metabolism seen in cancer cells simply an adaptation to energy demand, or is it really important for driving cancer?”

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    Targeting tumour metabolism. Nat Rev Drug Discov 9, 503–504 (2010). https://doi.org/10.1038/nrd3215

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    • DOI: https://doi.org/10.1038/nrd3215

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