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In December 2009, ecallantide (Kalbitor; Dyax) — a recombinant protein inhibitor of plasma kallikrein — was approved by the US FDA for the treatment of acute attacks of hereditary angioedema.

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Figure 1: Pathogenesis of hereditary angioedema and therapeutic interventions.


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Competing interests

B.Z. has participated in research with Lev Pharmaceuticals and Pharming AG, and has been a paid consultant for Dyax Inc., Jerini, Shire, CSL Behring and ViroPharma.

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Zuraw, B., Yasothan, U. & Kirkpatrick, P. Ecallantide. Nat Rev Drug Discov 9, 189–190 (2010).

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