Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • From the Analyst's Couch
  • Published:

Pharmaceutical R&D: the road to positive returns

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Improving the return on small-molecule R&D.
Figure 2: Output of model.

Author information

Authors and Affiliations


Supplementary information

Supplementary information S1 (box)

Methodology to estimate the internal rate of return on R&D investments (PDF 296 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

David, E., Tramontin, T. & Zemmel, R. Pharmaceutical R&D: the road to positive returns. Nat Rev Drug Discov 8, 609–610 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing