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The 'big pharma' dilemma: develop new drugs or promote existing ones?

Nature Reviews Drug Discovery volume 8, pages 533–534 (2009)Cite this article

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Figure 1: Trends in resource allocation to SG&Amp;A, R&D and COGS in the pharmaceutical industry: 1975–2007.

References

  1. Loscalzo, J. The NIH budget and the future of biomedical research. N. Engl. J. Med. 354, 1665–1667 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. DiMasi, J. A., Hansen, R. W. & Grabowski, H. G. The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151–185 (2003).

    Article  PubMed  Google Scholar 

  3. Sewing, A. et al. Helping science to succeed: improving processes in R&D. Drug Discov. Today 13, 227–233 (2008).

    Article  PubMed  Google Scholar 

  4. Gagnon, M. A. & Lexchin, J. The cost of pushing pills: a new estimate of pharmaceutical promotion expenditures in the United States. PLoS Med. 5, e1 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Donohue, J.M., Cevasco, M. & Rosenthal, M. B. A decade of direct-to-consumer advertising of prescription drugs. N. Engl. J. Med. 357, 673–681 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Wharton Research Data Services (WRDS) [online], (2009).

  7. Lev, B. Intangibles: Management, Measurement, and Reporting (Brookings Institution Press, Washington D.C., 2001).

    Google Scholar 

  8. Chan, L.K.C., Lakonishok, J. & Sougiannis, T. The stock market valuation of research and development expenditures. J. Finance LVI(6), 2431–2456 (2001).

    Article  Google Scholar 

  9. Bebchuk, L .A. & Fried, J. M. Pay Without Performance (Harvard University Press, Massachusetts, 2006).

    Book  Google Scholar 

  10. Kothari, S.P., Laguerre, T.E. & Leone, A.J. Capitalization versus expensing: evidence on the uncertainty of future earnings from capital expenditures versus R&D outlays. Rev. Account Stud. 7, 355–382 (2002).

    Article  Google Scholar 

  11. Lev, B. & Sougiannis, T. The capitalization, amortization and value-relevance of R&D. J. Account Econ. 21, 107–138 (1996).

    Article  Google Scholar 

  12. Cuatrecasas, P. Drug discovery in jeopardy. J. Clin. Invest. 116, 2837–2842 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Dan Weiss is at Leon Recanati Graduate School of Business Administration, Tel Aviv University, Tel Aviv, Israel.,

    Dan Weiss

  2. Prasad Naik is at the Graduate School of Management, University of California at Davis, California, USA.,

    Prasad Naik

  3. Ram Weiss is at the Department of Human Nutrition and Metabolism and Braun School of Public Health, Hebrew University School of Medicine, PO Box 12272 Jerusalem 91120, Israel.,

    Ram Weiss

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  1. Dan Weiss
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  2. Prasad Naik
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  3. Ram Weiss
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Correspondence to Ram Weiss.

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Weiss, D., Naik, P. & Weiss, R. The 'big pharma' dilemma: develop new drugs or promote existing ones?. Nat Rev Drug Discov 8, 533–534 (2009). https://doi.org/10.1038/nrd2923

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