Abstract
In May 2008, febuxostat (Adenuric; Ipsen), an inhibitor of xanthine oxidase, was granted marketing authorization by the European Commission for the treatment of chronic hyperuricaemia in conditions in which urate deposition has occurred, such as gouty arthritis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release
Nature Communications Open Access 12 August 2023
-
Efficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles
Nature Communications Open Access 06 April 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Choi, H. K. et al. Pathogenesis of gout. Ann. Intern. Med. 143, 499–516 (2005).
Zhang, W. et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann. Rheum. Dis. 65, 1312–1324 (2006).
Pascual, E. & Sivera, F. Therapeutic advances in gout. Curr. Opin. Rheumatol. 19, 122–127 (2007).
Okamoto, K. et al. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J. Biol. Chem. 278, 1848–1855 (2003).
Osada, Y. et al. Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur. J. Pharmacol. 241, 183–188 (1993).
Komoriya, K. et al. Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees. Eur. J. Pharmacol. 250, 455–460 (1993).
European Medicines Agency (EMEA). European Public Assessment Report – Adenuric. EMEA web site [online], (2008).
Schumacher, H. R. Jr et al. Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial. Arthritis Rheum. 59, 1540–1548 (2008).
Becker, M. A. et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N. Engl. J. Med. 353, 2450–2461 (2005).
Pascual, E. & Sivera, F. The time required for disappearance of urate crystals from synovial fluid after successful hypouricemic treatment relates to the duration of gout. Ann. Rheum. Dis. 66, 1056–1058 (2007).
Perez-Ruiz, F. et al. Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout. Arthritis Rheum. 47, 356–360 (2002).
Singh, J. et al. Quality of care for gout in the US needs improvement. Arthritis Rheum. 57, 822–829 (2007).
Mikuls, T. et al. Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD). Rheumatology 44, 1038–1042 (2005).
Reinders, M. K. et al. A randomised controlled trial on the efficacy and tolerability with dose-escalation of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day in patients with gout. Ann. Rheum. Dis. 16 Jul 2008 (doi:10.1136/ard.2008.091462).
IMS MIDAS (2007).
Febuxostat for the management of hyperuricaemia in patients with gout. National Institute for Health and Clinical Excellence web site [online], (2008).
Hauber, A. Bear Sterns Equity Research Report (Bear Sterns, 22 Feb 2008).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
E.P. has given a presentation on gout diagnosis at a symposium on febuxostat organized by Ipsen.
Rights and permissions
About this article
Cite this article
Pascual, E., Sivera, F., Yasothan, U. et al. Febuxostat. Nat Rev Drug Discov 8, 191–192 (2009). https://doi.org/10.1038/nrd2831
Issue Date:
DOI: https://doi.org/10.1038/nrd2831
This article is cited by
-
NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release
Nature Communications (2023)
-
Efficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles
Nature Communications (2022)
-
Pegloticase
Nature Reviews Drug Discovery (2011)