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Do molecularly targeted agents in oncology have reduced attrition rates?

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Figure 1: Number of agents in clinical development with oncology as the primary indication in the period 1995–2007.
Figure 2: Phase transition probability including projects with no development reported (NDR).
Figure 3: Phase transition probability excluding projects with no development reported (NDR).


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Correspondence to Ian Walker.

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Competing interests

Herbie Newell is an employee of Cancer Research UK and Newcastle University, UK. He receives an honorarium as Editor of the journal Cancer Chemotherapy and Pharmacology, and holds research grant funding from UK and European charity and governmental bodies, and Astex Therapeutics and AstraZeneca/KuDOS Pharmaceuticals. Ian Walker is an employee of Cancer Research Technology, with no conflict of interest.

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List of oncology agents analysed (PDF 300 kb)

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Walker, I., Newell, H. Do molecularly targeted agents in oncology have reduced attrition rates?. Nat Rev Drug Discov 8, 15–16 (2009).

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