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Trends in the globalization of clinical trials

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Figure 1: Density of actively recruiting clinical sites of biopharmaceutical clinical trials worldwide.


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We thank F. L. Douglas and H. Golub of the Harvard–MIT Division of Health Sciences and Technology, and M. S. Trusheim, MIT Sloan School, for comments on early drafts. Funding: MIT's Hugh Hampton Young Memorial Fellowship (F.A.T); Louis E. Seley Chaired Professorship (E.R.B).Preliminary results described in Science Master Thesis (F.A.T) entitled: The Globalization of Clinical Drug Development, submitted to the Harvard–MIT Division of Health Sciences and Technology.

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Correspondence to Ernst R. Berndt.

Supplementary information

Supplementary information S1 (box)

Methodology of analysis. (PDF 105 kb)

Supplementary information S2 (box)

Recent evolution of regional shares of biopharmaceutical clinical trial sites. (PDF 140 kb)

Supplementary information S3 (table)

Top 50 countries Ranked by number of trial Sites – shares and trial capacity. (PDF 468 kb)

Supplementary information S4 (table)

Top 50 countries ranked by average relative annual growth rates. (PDF 510 kb)

Supplementary information S5 (table)

Types of trial by region as of April 12, 2008 (in percent) (PDF 130 kb)

Supplementary information S6 (table)

Regional distribution of trial type as of April 12, 2007 (in percent) (PDF 107 kb)

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Thiers, F., Sinskey, A. & Berndt, E. Trends in the globalization of clinical trials. Nat Rev Drug Discov 7, 13–14 (2008).

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