Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Fresh from the Pipeline
  • Published:

Panitumumab

Abstract

Panitumumab

In September 2006, panitumumab (Vectibix; Amgen), a fully human antibody against the epidermal growth factor receptor (EGFR), was approved by the FDA for the treatment of patients with EGFR-expressing metastatic colorectal cancer with disease progression on or following fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemotherapy regimens.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: EGFR signalling and panitumumab.

References

  1. Goldberg, R. M. Therapy for metastatic colorectal cancer. The Oncologist 11, 981–987 (2006)

    Article  CAS  Google Scholar 

  2. Parkin, D. M. et al. Cancer burden in the year 2000. The global picture. Eur. J. Cancer 37, S4–S66 (2001).

    Article  Google Scholar 

  3. Goldberg. R. M. et al. Cetuxiumab. Nature. Rev. Drug Discov. 4, S10–S11 (2005).

    Article  Google Scholar 

  4. Baselga, J. Why the epidermal growth factor receptor? The rationale for cancer therapy. The Oncologist 7 (S4), 2–8 (2002).

    Article  CAS  Google Scholar 

  5. Salomon, D. S. et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19, 183–232 (1995).

    Article  CAS  Google Scholar 

  6. Mendez, M. J. et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nature Genet. 15, 146–156 (1997)

    Article  CAS  Google Scholar 

  7. Yang, X. D. et al. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 59, 1236–1243 (1999).

    CAS  PubMed  Google Scholar 

  8. Yang, X. D. et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 38, 17–23 (2001)

    Article  CAS  Google Scholar 

  9. FDA labelling information [online], <http://www.fda.gov/cder/foi/label/2006/125147s0000lbl.pdf> (2006).

  10. Yarden, Y. & Sliwkowski, M. X. Untangling the ErbB signalling network. Nature Rev. Mol. Cell Biol. 2, 127–137 (2001).

    Article  CAS  Google Scholar 

  11. Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335–2442 (2004).

    Article  CAS  Google Scholar 

  12. Saltz, L. et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc. Am. Soc. Clin. Oncol. 20, A7 (2001).

    Google Scholar 

  13. Saltz, L. B. et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 22, 1201–1208 (2004).

    Article  CAS  Google Scholar 

  14. Tabernero, J. et al. Optimal dose of cetuximab (C) given every 2 weeks (q2w): A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (q1w) and q2w schedules in patients (pts) with metastatic colorectal cancer (mCRC). J. Clin. Oncol. 24, 18S (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saltz, L., Easley, C. & Kirkpatrick, P. Panitumumab. Nat Rev Drug Discov 5, 987–988 (2006). https://doi.org/10.1038/nrd2204

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrd2204

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing