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Quadrivalent human papillo-mavirus recombinant vaccine

Nature Reviews Drug Discovery volume 5, pages 629630 (2006) | Download Citation

Subjects

In June 2006, a quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil; Merck) was approved by the US FDA for the prevention of several diseases, including cervical cancer, that are caused by these types of human papillomavirus.

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References

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    et al. Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc. Natl Acad. Sci. USA 89, 12180–12184 (1992).

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    et al. A controlled trial of a human papillomavirus type 16 vaccine. N. Engl. J. Med. 347, 1645–1651 (2002).

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    et al. Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre Phase II efficacy trial. Lancet Oncol. 6, 271–278 (2005).

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    et al. Immunologic responses following administration of a vaccine targeting human papillomavirus types 6, 11, 16, and 18. Vaccine 24, 5571–5583 (2006).

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Author information

Affiliations

  1. Christopher Crum is at the Department of Pathology, Brigham and Women's Hospital, 75 Francis Street Boston, Massachusetts 02115, USA.  cpcrum@bics.bwh.harvard.edu

    • Christopher Crum
  2. Carole Jones is at IMS Health, 7 Harewood Avenue, London NW1 6JB, UK.  cjones@uk.imshealth.com

    • Carole Jones
  3. Peter Kirkpatrick is at Nature Reviews Drug Discovery.  p.kirkpatrick@nature.com

    • Peter Kirkpatrick

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About this article

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DOI

https://doi.org/10.1038/nrd2117

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