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Abatacept

Nature Reviews Drug Discovery volume 5, pages 185–186 (2006)Cite this article

Abstract

In December 2005, abatacept (Orencia; Bristol-Myers Squibb), a fusion protein that selectively modulates a costimulatory signal necessary for T-cell activation, was approved by the US FDA for the treatment of patients with rheumatoid arthritis who have had an inadequate response to other drugs. It is the first selective costimulation modulator to be approved.

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Figure 1: Activity of abatacept.

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Author information

Affiliations

  1. the Department of Medicine, University of Alabama, 1717 6th Ave South, Birmingham, 35294-7201, Alabama, USA

    Larry Moreland

  2. IMS Health, 7 Harewood Avenue, London, NW1 6JB, UK

    Guy Bate

  3. Nature Reviews Drug Discovery, UK

    Peter Kirkpatrick

Authors
  1. Larry Moreland
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  2. Guy Bate
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  3. Peter Kirkpatrick
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Moreland, L., Bate, G. & Kirkpatrick, P. Abatacept. Nat Rev Drug Discov 5, 185–186 (2006). https://doi.org/10.1038/nrd1989

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