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Pregabalin

Abstract

In July 2004, pregabalin (Lyrica; Pfizer) was approved in Europe for the treatment of peripheral neuropathic pain and as an adjunctive therapy for partial seizures in patients with epilepsy. Approval by the US FDA for the management of neuropathic pain associated with diabetic peripheral neuropathy and post-herpetic neuralgia followed in December 2004.

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References

  1. 1

    Woolf, C. J. & Mannion, R. J. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353, 1959–1964 (1999).

  2. 2

    Dworkin, R. H. et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch. Neurol. 60, 1524–1534 (2003).

  3. 3

    Bryans, J. S. & Wustrow, D. J. 3-substituted GABA analogs with central nervous system activity: a review. Med. Res. Rev. 19, 149–177 (1999).

  4. 4

    Belliotti, T. R. et al. Structure–activity relationships of pregabalin and analogues that target the α2-δ protein. J. Med. Chem. 48, 2294–2307 (2005).

  5. 5

    Bramwell, S. R. et al. The analgesic actions of pregabalin are mediated through its binding to the α2δ-1 subunit of voltage-gated calcium channels. Abs. Soc. Neurosci. Ann. Meeting program 523.19 (2004).

  6. 6

    Electronic medicines compendium [online], <http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=14651> (2004).

  7. 7

    Lesser, H. et al. Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology 63, 2104–2110 (2004).

  8. 8

    Rosenstock, J. et al. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 110, 628–638 (2004).

  9. 9

    Richter, R. W. et al. Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J. Pain 6, 253–260 (2005).

  10. 10

    Dworkin, R. H. et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 60, 1274–1283 (2003).

  11. 11

    Sabatowski, R. et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain 109, 26–35 (2004).

  12. 12

    Beydoun, A. et al. Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy. Neurology 64, 475–480 (2005).

  13. 13

    Arroyo, S. et al. Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose–response study in adults with partial seizures. Epilepsia 45, 20–27 (2004).

  14. 14

    Drugs@FDA [online], <http://www.fda.gov/cder/foi/appletter/2004/21723ltr.pdf> (2004).

  15. 15

    Sawynok, J. et al. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J. Psychiatry Neurosci. 26, 21–29 (2001).

  16. 16

    Kalso, E. et al. (eds). Opioid Sensitivity of Chronic Noncancer Pain (IASP, Seattle, 1999).

  17. 17

    Woolf, C. J. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann. Intern. Med. 140, 441–451 (2004).

  18. 18

    Raja, S. N. et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 59, 1015–1021 (2002).

  19. 19

    Gilron, I. et al. Morphine, gabapentin, or their combination for neuropathic pain. N. Engl. J. Med. 352, 1324–1334 (2005).

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Correspondence to Robert H. Dworkin or Peter Kirkpatrick.

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Figure 1: Chemical structures of GABA, gabapentin and pregabalin.