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The first study pointing to a role for the endocannabinoids as orexigenic mediators.
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The first example of the use of inhibitors of endocannabinoid inactivation as potential therapeutic agents.
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A typical example of a protective role played 'on demand' by endocannabinoids in a peripheral organ.
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The antiproliferative effects of the endocannabinoids against cancer cells in vitro were examined for the first time in this study. Together with reference 73, this marked the beginning of studies on the possible anticancer function of the endocannabinoid system.
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Cloning of the major enzyme catalysing anandamide biosynthesis.
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Reports the cloning of the first enzymes catalysing the biosynthesis of an endocannabinoid, 2-arachidonoylglycerol.
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An important study confirming conclusively that FAAH can be targeted for the development of new antihyperalgesic drugs.
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Reports the cloning of the first 'endocannabinoid enzyme', FAAH, a potential therapeutic target for analgesic and anxiolytic compounds.
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Describes the development of the first selective cannabinoid CB1-receptor antagonist, rimonabant, which is now in Phase III clinical trials being tested as an anti-obesity agent and against nicotine dependence.
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The first very large controlled clinical study with THC and Cannabis extract as potential treatments for a human disorder.
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