Abstract

In November 2002, atomoxetine hydrochloride (Strattera; Eli Lilly), a noradrenaline-reuptake inhibitor, was approved by the US FDA for the treatment of attention-deficit–hyperactivity disorder. As the first non-stimulant drug for this common but controversial condition, and also the first approved for the treatment of adults, what influence has it had on the market since its introduction?
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References
Elia, J. et al. Treatment of attention-deficit–hyperactivity disorder. N. Engl. J. Med. 340, 780–788 (1999).
Zametkin, A. J. & Ernst, M. Problems in the management of attention-deficit–hyperactivity disorder. N. Engl. J. Med. 340, 40–46 (1999).
Wilens, T. E. et al. Attention deficit/hyperactivity disorder across the lifespan. Annu. Rev. Med. 53, 113–131 (2002).
Solanto, M. V. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav. Brain Res. 130, 65–71 (2002).
Biederman, J. & Spencer, T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol. Pyschiatry 46, 1234–1242 (1999).
Wong, D. T. et al. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J. Pharmacol. Exp. Ther. 222, 61–65 (1982).
Zerbe, R. L. et al. Clinical pharmacology of tomoxetine, a potential antidepressant. J. Pharmacol. Exp. Ther. 232, 139–143 (1985).
Spencer, T. et al. Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder. Am. J. Psychiatry 155, 693–695 (1998).
FDA Drug Approvals List [online], (cited 6 Mar 2004). <http://www.fda.gov/cder/foi/label/2002/21411_strattera_lbl.pdf> (2002).
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Garland, M., Kirkpatrick, P. Atomoxetine hydrochloride. Nat Rev Drug Discov 3, 385–386 (2004). https://doi.org/10.1038/nrd1387
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DOI: https://doi.org/10.1038/nrd1387