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On 13 May 2003, Bortezomib (Velcade; Millenium) became the first proteasome inhibitor to be approved by the US FDA. Bortezomib was approved for multiple myeloma, a blood cancer that affects two to three people per 100,000, in record time — four months — on the basis of positive outcomes in early-phase trials.

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Figure 1: Bortezomib and NF-κB.
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Correspondence to Andrew Paramore.

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Paramore, A., Frantz, S. Bortezomib. Nat Rev Drug Discov 2, 611–612 (2003) doi:10.1038/nrd1159

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