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Enfuvirtide

Abstract

Enfuvirtide (Fuzeon; Trimeris/Roche), the first in a new class of anti-HIV drugs that inhibit the entry of the virus into cells, was approved by the US FDA in March 2003 for the treatment of HIV-1 infection in treatment-experienced patients. Is it likely to become a blockbuster?

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Figure 1: Mode of action of enfuvirtide.
Figure 2: Market for anti-HIV drugs.

References

  1. Lalezari, J. P. et al. Enfuvirtide, an HIV-1 fusion inhibitor for drug-resistant HIV infection in North and South America. N. Engl. J. Med. (2003) Mar 13 (doi: 10.1056/NEJMoa035026)

  2. De Clercq, E. Strategies in the design of antiviral drugs. Nature Rev. Drug Discov. 1, 13–25 (2002).

    Article  CAS  Google Scholar 

  3. Wild, C. T. et al. Peptides corresponding to a predictive α-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc. Natl Acad. Sci. USA 91, 9770–9774 (1994).

    Article  CAS  Google Scholar 

  4. Kilby, J. M. et al. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nature Med. 4, 1302–1307 (1998).

    Article  CAS  Google Scholar 

  5. FDA Drug Approvals List [online] (cited 28 March 2003) <http://www.fda.gov/cder/foi/label/2003/021481lbl.pdf> (2003).

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Correspondence to Jason LaBonte.

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LaBonte, J., Lebbos, J. & Kirkpatrick, P. Enfuvirtide. Nat Rev Drug Discov 2, 345–346 (2003). https://doi.org/10.1038/nrd1091

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  • DOI: https://doi.org/10.1038/nrd1091

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