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In September 2002, eplerenone (Inspra; Pharmacia), the first selective aldosterone receptor antagonist, was approved by the FDA for the treatment of hypertension. Will it become as successful as established blockbuster drugs that also target the renin–angiotensin–aldosterone system?

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Figure 1: Aldosterone antagonism.
Figure 2: Number of cases of hypertension.
Figure 3: Sales for antihypertensive drugs in US $ billion.


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Correspondence to Ruth Brown.

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Peter Kirkpatrick is Senior Editor of Nature Reviews Drug Discovery. Ruth Brown and Jeremy Quirk are Analysts

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Brown, R., Quirk, J. & Kirkpatrick, P. Eplerenone. Nat Rev Drug Discov 2, 177–178 (2003).

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