Abstract
Congruence between in vitro and animal models of disease and the corresponding human condition is a fundamental assumption of much biomedical research, but it is one that is rarely critically assessed. In the absence of such critical assessment, the assumption of congruence may be invalid for most models. Much more open discussion of this issue is required if biomedical research is to be clinically productive.
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References
Hesse, H. Magister Ludi (Bantam Press, New York, 1970) Originally published as Das Glasperlenspiel, Fretz and Wasmuth Verlag, Zurich, 1943.
Reynolds, L. M., Dalton, C. F. & Reynolds, G. P. Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. Neurosci. Lett. 309, 193–196 (2001).
Witt, M. R. & Nielsen, M. Characterisation of the influence of unsaturated free fatty acids on brain GABA/benzodiazepine receptor binding in vitro. J. Neurochem. 62, 1432–1439 (1994).
Pearson, H. Surviving a knock-out blow. Nature 415, 8–9 (2002).
Horrobin, D. F. Innovation in the pharmaceutical industry. J. R. Soc. Medicine 93, 341–345 (2000).
Horrobin D. F. Realism in drug discovery — could Cassandra be right? Nature Biotechnol. 19, 1099–1100 (2001).
Persson, C. G., Erjefalt, J. S., Uller, L., Andersson, M. & Greiff, L. Unbalanced research. Trends Pharmacol. Sci. 22, 538–541 (2001).
Rees J. Post-genome integrative biology: so that's what they call clinical science. Clin. Med. 1, 393–400 (2001).
Rosenberg, L. Physician–scientists — endangered and essential. Science 283, 331–332 (1999).
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Horrobin, D. Modern biomedical research: an internally self-consistent universe with little contact with medical reality?. Nat Rev Drug Discov 2, 151–154 (2003). https://doi.org/10.1038/nrd1012
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DOI: https://doi.org/10.1038/nrd1012
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