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Overcoming the legal and regulatory barriers to drug repurposing


Drug repurposing has been proposed as a strategy to develop new therapies that has fewer risks, lower costs and shorter timelines than developing completely new drugs. However, the potential of this strategy has not been as widely realized as hoped, in part owing to legal and regulatory barriers. Here, we highlight these barriers and consider how they could be overcome.

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  1. Ashburn, T. T. & Thor, K. B. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 3, 673–683 (2004).

    Article  CAS  Google Scholar 

  2. Grabowski, H. Follow-on biologics: data exclusivity and the balance between innovation and competition. Nat. Rev. Drug Discov. 7, 479–488 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Alasdair Breckenridge.

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Breckenridge, A., Jacob, R. Overcoming the legal and regulatory barriers to drug repurposing. Nat Rev Drug Discov 18, 1–2 (2019).

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