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A call for a global ‘bigger’ data approach to Alzheimer disease

Clinical trials for Alzheimer disease drugs have an exceptionally high failure rate, discouraging investment in the field despite the unmet medical need. Drug developers need to more effectively harness existing and emerging data and digital technologies to improve the likelihood of success.

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  1. Cummings, J., Morstorf, T. & Zhong, K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res. Ther. 6, 37 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Zhang, R., Simon, G. & Yu, F. Advancing Alzheimer’s research: a review of big data promises. Int. J. Med. Inform. 106, 48–56 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Khozin, S., Pazdur, R. & Shah, A. INFORMED: an incubator at the US FDA for driving innovations in data science and agile technology. Nat. Rev. Drug Discov. (2018).

    Article  PubMed  Google Scholar 

  4. Kulmala, J., Ngandu, T. & Kivipelto, M. Prevention matters: time for global action and effective implementation. J. Alzheimers Dis. (2018).

    Article  PubMed  Google Scholar 

  5. Bourla, A., Ferreri, F., Ogorzelec, L., Guinchard, C. & Mouchabac, S. Assessment of mood disorders by passive data gathering: the concept of digital phenotype versus psychiatrist’s professional culture. Encephale 44, 168–175 (2017).

    Article  PubMed  Google Scholar 

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Correspondence to Eric Perakslis.

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Pragmatic Trials of Managing Multimorbidity in Alzheimer’s Disease:

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Perakslis, E., Riordan, H., Friedhoff, L. et al. A call for a global ‘bigger’ data approach to Alzheimer disease. Nat Rev Drug Discov 18, 319–320 (2019).

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