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Malhotra, N. et al. RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci. Immunol. 3, eaao6923 (2018).
This study shows that expression of retinoid-related orphan receptor-α (RORα) in skin-resident Treg cells is important for restraining allergic skin inflammation.
Pesenacker, A. M., Broady, R. & Levings, M. K. Control of tissue-localized immune responses by human regulatory T cells. Eur. J. Immunol. 45, 333–343 (2015).
Akimova, T. et al. Human lung tumor FOXP3+ Tregs upregulate four “Treg-locking” transcription factors. JCI Insight 2, 94075 (2017).
Burzyn, D. et al. A special population of regulatory T cells potentiates muscle repair. Cell 155, 1282–1295 (2013).
This study introduces the concept that Treg cells can participate in the repair of injured tissue through the factors they produce. Treg cells repair injured muscle through the production of amphiregulin.
Arpaia, N. et al. A distinct function of regulatory T cells in tissue protection. Cell 162, 1078–1089 (2015).
Zaiss, D. M. et al. Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity 38, 275–284 (2013).
Sanchez Rodriguez, R. et al. Memory regulatory T cells reside in human skin. J. Clin. Invest. 124, 1027–1036 (2014).
Nosbaum, A. et al. Cutting edge: regulatory T cells facilitate cutaneous wound healing. J. Immunol. 196, 2010–2014 (2016).
Ali, N. et al. Regulatory T cells in skin facilitate epithelial stem cell differentiation. Cell 169, 1119–1129 (2017).
This study provides another example of Treg cells being involved in tissue repair and/or regeneration. Skin-resident Treg cells were found to express preferentially high levels of the NOTCH ligand family member jagged 1, which promoted the function of skin stem cells.
Zacchigna, S. et al. Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction. Nat. Commun. 9, 2432 (2018).
Bieber, A. J., Kerr, S. & Rodriguez, M. Efficient central nervous system remyelination requires T cells. Ann. Neurol. 53, 680–684 (2003).
Dombrowski, Y. et al. Regulatory T cells promote myelin regeneration in the central nervous system. Nat. Neurosci. 20, 674–680 (2017).