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Poor medication adherence in clinical trials: consequences and solutions

Nature Reviews Drug Discovery volume 16, pages 149–150 (2017)Cite this article

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Abstract

Poor adherence to medicines in clinical trials can undermine the value of the trials; for example, by compromising estimates of the benefits and risks of a medicine. In this article, we highlight such consequences and also discuss approaches to tackle this problem.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, L69 3BX, UK

    Alasdair Breckenridge

  2. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK

    Jeffrey K. Aronson

  3. Department of Medicine, Stanford University School of Medicine, Stanford, 94305, California, USA

    Terrence F. Blaschke

  4. Global Health, Bill and Melinda Gates Foundation, Seattle, 98102, USA

    Dan Hartman

  5. Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, California 94158, USA.,

    Carl C. Peck

  6. Westrock Healthcare, Vise, 4600, Belgium

    Bernard Vrijens

Authors
  1. Alasdair Breckenridge
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  2. Jeffrey K. Aronson
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  3. Terrence F. Blaschke
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  4. Dan Hartman
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  5. Carl C. Peck
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  6. Bernard Vrijens
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Corresponding author

Correspondence to Alasdair Breckenridge.

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The authors declare no competing financial interests.

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FURTHER INFORMATION

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

SPIRIT 2013 Statement

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Breckenridge, A., Aronson, J., Blaschke, T. et al. Poor medication adherence in clinical trials: consequences and solutions. Nat Rev Drug Discov 16, 149–150 (2017). https://doi.org/10.1038/nrd.2017.1

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