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Poor medication adherence in clinical trials: consequences and solutions

Abstract

Poor adherence to medicines in clinical trials can undermine the value of the trials; for example, by compromising estimates of the benefits and risks of a medicine. In this article, we highlight such consequences and also discuss approaches to tackle this problem.

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Correspondence to Alasdair Breckenridge.

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The authors declare no competing financial interests.

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CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

SPIRIT 2013 Statement

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Breckenridge, A., Aronson, J., Blaschke, T. et al. Poor medication adherence in clinical trials: consequences and solutions. Nat Rev Drug Discov 16, 149–150 (2017). https://doi.org/10.1038/nrd.2017.1

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  • DOI: https://doi.org/10.1038/nrd.2017.1

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