Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Legacy data sharing to improve drug safety assessment: the eTOX project

Nature Reviews Drug Discovery volume 16, pages 811–812 (2017)Cite this article

Subjects

Abstract

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Obiol-Pardo, C. et al. A multiscale simulation system for the prediction of drug-induced cardiotoxicity. J. Chem. Inf. Model. 51, 483–492 (2011).

    Article  CAS  Google Scholar 

  2. Carbonell, P. et al. Hepatotoxicity prediction by systems biology modeling of disturbed metabolic pathways using gene expression data. ALTEX 34, 219–234 (2017)10.14573/altex.1602071.

    Article  PubMed  Google Scholar 

  3. Harvey, J. et al. Management of organic impurities in small molecule medicinal products: deriving safe limits for use in early development. Regul. Toxicol. Pharmacol. 84, 116–123 (2017)10.1016/j.yrtph.2016.12.011.

    Article  CAS  PubMed  Google Scholar 

  4. Carrió, P. et al. Applicability Domain Analysis (ADAN): a robust method for assessing the reliability of drug property predictions. J. Chem. Inf. Model. 54, 1500–1511 (2014).

    Article  Google Scholar 

  5. Hewitt, M. et al. Ensuring confidence in predictions: a scheme to assess the scientific validity of in silico models. Adv. Drug Deliv. Rev. 86, 101–111 (2015)10.1016/j.addr.2015.03.005.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra, Barcelona, 08003, Spain

    Ferran Sanz & Manuel Pastor

  2. Novartis Institute for Biomedical Research, Basel, CH-4002, Switzerland

    François Pognan & Philippe Marc

  3. Bayer AG, Berlin, 13353, Germany

    Thomas Steger-Hartmann & Joerg Wichard

  4. Synapse Research Management Partners, Barcelona, 08007, Spain

    Carlos Díaz & Montserrat Cases

  5. Lhasa Ltd, Leeds, LS11 5PS, UK

    Katharine Briggs & David K. Watson

  6. Molecular Networks GmbH, Nürnberg, 90411, Germany

    Thomas Kleinöder & Chihae Yang

  7. Sanofi, Frankfurt am Main, 65926, Germany

    Alexander Amberg

  8. GlaxoSmithKline Research and Development Ltd, Stevenage, SG1 2NY, UK

    Maria Beaumont

  9. University of Leicester, Leicester, LE1 7RH, UK

    Anthony J. Brookes

  10. Technical University of Denmark (DTU), Lyngby, 2800, Denmark

    Søren Brunak

  11. Liverpool John Moores University, Liverpool, L3 3AF, UK

    Mark T. D. Cronin

  12. Universität Wien, Vienna, 1090, Austria

    Gerhard F. Ecker

  13. Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, 30625, Germany

    Sylvia Escher

  14. Pfizer Ltd, Groton, Connecticut 06340, USA. Current affiliation: AstraZeneca, Waltham, Massachusettts 02451, USA,

    Nigel Greene

  15. ESTEVE, Barcelona, 08041, Spain

    Antonio Guzmán

  16. European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridge, UK

    Anne Hersey

  17. UCB Pharma SA, Brussels, 1070, Belgium

    Pascale Jacques

  18. Janssen Pharmaceutica NV, Beerse, 2340, Belgium

    Lieve Lammens

  19. Chemotargets SL, Barcelona, 08003, Spain

    Jordi Mestres

  20. F. Hoffmann-La Roche AG, Basel, CH-4070, Switzerland

    Wolfgang Muster

  21. H. Lundbeck A/S, Copenhagen, 2500, Denmark

    Helle Northeved

  22. AstraZeneca AB, SK10 2NA Cheshire, UK. Current affiliation: Lhasa Ltd, Leeds LS11 5PS, UK,

    Marc Pinches

  23. Universitat Politècnica de València, València, 46022, Spain

    Javier Saiz

  24. Servier, Orléans, 45000, France

    Nicolas Sajot

  25. ICREA, 08010 Barcelona, Spain & Barcelona Supercomputing Center (BSC), Barcelona, 08034, Spain

    Alfonso Valencia

  26. Erasmus Universitair Medisch Centrum, Rotterdam, 3015 CE, The Netherlands

    Johan van der Lei

  27. Vrije Universiteit Amsterdam, Amsterdam, 1081, The Netherlands

    Nico P. E. Vermeulen

  28. Boehringer Ingelheim International GmbH, Biberach an der Riss, 88379, Germany

    Esther Vock

  29. Inte:Ligand GmbH, Vienna, 1070, Austria

    Gerhard Wolber

  30. Lead Molecular Design S.L., Sant Cugat del Vallès, 08172, Spain

    Ismael Zamora

Authors
  1. Ferran Sanz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. François Pognan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Steger-Hartmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carlos Díaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Montserrat Cases
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manuel Pastor
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Philippe Marc
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Joerg Wichard
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Katharine Briggs
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. David K. Watson
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Thomas Kleinöder
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Chihae Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Alexander Amberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Maria Beaumont
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Anthony J. Brookes
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Søren Brunak
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Mark T. D. Cronin
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Gerhard F. Ecker
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Sylvia Escher
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Nigel Greene
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Antonio Guzmán
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Anne Hersey
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Pascale Jacques
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Lieve Lammens
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Jordi Mestres
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Wolfgang Muster
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Helle Northeved
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Marc Pinches
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Javier Saiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Nicolas Sajot
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Alfonso Valencia
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Johan van der Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Nico P. E. Vermeulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Esther Vock
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Gerhard Wolber
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Ismael Zamora
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

eTOX

Corresponding authors

Correspondence to Ferran Sanz or François Pognan.

Ethics declarations

Competing interests

Some of the authors are employed in the pharmaceutical industry or in small and medium-sized enterprises, as indicated in the author affliations.

Supplementary information

Supplementary information S1 (box)

eTOX-related web sites and publications (PDF 173 kb)

Related links

Related links

FURTHER INFORMATION

eTOX

eTOXlab

eTOXsys

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sanz, F., Pognan, F., Steger-Hartmann, T. et al. Legacy data sharing to improve drug safety assessment: the eTOX project. Nat Rev Drug Discov 16, 811–812 (2017). https://doi.org/10.1038/nrd.2017.177

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrd.2017.177

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research