A Human Knockout Project would systematically search for loss-of-function genetic mutations in humans to help uncover new drug targets.
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Mullard, A. Calls grow to tap the gold mine of human genetic knockouts. Nat Rev Drug Discov 16, 515–518 (2017). https://doi.org/10.1038/nrd.2017.139
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DOI: https://doi.org/10.1038/nrd.2017.139
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